Minnesota soars into Philadelphia for a marquee clash on Monday night as we examine the latest Vikings vs Eagles odds. 

Both teams came into the season with high expectations. They got their seasons started on the right foot with a win in Week 1. Which squad will take it a step further with an early season signature win? 

Vikings vs Eagles odds

Per BetMGM

  • Betting Favorite: Eagles (-2.5)
  • Moneyline Odds: Vikings +120, Eagles -145
  • Point Total: 49 (O/U)
  • Location: Lincoln Financial Field, Philadelphia, PA
  • Time/Network: 8:30 PM EST on ABC

In one of the tightest lines of Week 2, the Eagles open as narrow home favorites. 

While Kirk Cousins and Jalen Hurts each has plenty of critics, these two teams showcased their offensive prowess in Week 1, and oddsmakers have taken note, setting the over/under at 49. 

This game will feature elite skill-level players, notably at wide receiver, with Justin Jefferson and AJ Brown looking to take the top off the opposing defenses.

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Vikings vs Eagles Injury Report

NFL betting strategy often relies on highlighting critical injuries. Before making any Vikings vs Eagles picks, it's important to sneak a glance at the injury report.

The Vikings enter Week 2 with both of their top 2022 draft picks – Lewis Cine and Andrew Booth – on the injury report. While both players were lauded prospects, neither is listed as a starter on the Vikings' depth chart.

Vikings Injury Report

  • CB Andrew Booth (Quad)
  •  DE Jonathan Bullard (Biceps)
  •  S Lewis Cine (Knee)

The Eagles enter Week 2 with eight players on their injury report, but all but one of them lack an injury designation. Their most notable injury news came from defensive end Derek Barnett landing on Injured Reserve after suffering a torn ACL in the opener.

Eagles Injury Report

  •  DE Fletcher Dox (Rest)
  •  G Landon Dickerson (Rest)
  •  DE Brandon Graham (Rest)
  •  OT Lane Johnson (Rest)
  •  C Jason Kelce (Rest)
  •  G Isaac Seumalo (Rest)
  • TE Jack Stoll (Ankle)
  •  DE Josh Sweat (Rest)

Vikings vs Eagles head-to-head 

The Vikings lead the Eagles by a narrow 15-14 margin in their all-time series, with the last meeting coming in the 2019 regular season. 

The Eagles won the most significant game in this head-to-head matchup with a dominating 38-7 victory in the NFC Conference Championship back in 2018. Philadelphia went on to win the Super Bowl that year.  

The Vikings are 4-2 ATS in their last six games in this series, but that dates all the way back to 2010.

Vikings recent record on the road

After opening the season with a rousing victory in front of their fans, this will be Minnesota's first road game of 2022. Here's a look at how they fared as the away team last year:

2021 Vikings road trends:

  • Straight up: 3-6
  • ATS: 5-4
  • ATS as an underdog: 3-2

Eagles recent record at Lincoln Financial Field

Philadelphia opened the season on the road with a win at Detroit. They will be eager to kick off their home opener here. 

2021 Eagles home trends:

  • Straight up: 3-5
  • ATS: 3-4-1
  • ATS as a favorite: 2-0-1

Vikings vs Eagles predictions

There is not a lot separating these teams in the latest Vikings vs Eagles odds.

Both teams were expected to win their first games, but neither went according to the script. The Vikings, favored by less than a field goal against the Packers at home, held the Packers to a paltry seven points on defense while moving the ball at will on offense. 

Justin Jefferson ran amok, hauling in nine catches for 184 yards and two touchdowns against a Packers defense that looked devoid of a plan to contain him. Dalvin Cook and Alexander Mattison each averaged 4.5 yards per carry, giving the Vikings a total of 126 yards on the ground over 28 rushing attempts.  

Philadelphia can pack a punch on offense. A.J. Brown immediately made his presence felt at receiver, catching 10 of Hurts' 18 completed passes for a total of 155 yards. 

With that said, the versatility of the Vikings' offense should pose all kinds of issues for an Eagles defense that ranked just 19th in defensive scoring last year and was gouged by Detroit in the second half of their Week 1 showdown. 

The Eagles went just 3-5 at home last year. Expect them to get off on the wrong foot again here.

Prediction Vikings +2.5

Vikings vs Eagles  Best Value Bet

  • AJ Brown over 74.5 yards (-115)
  • Justin Jefferson over 7.5 receptions (+115)
  • Vikings to win and over 40.5 points scored (+190)
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