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Notre Dame at Ohio State Preview – Odds, Spreads, & Moneylines

Author: American Gambler Staff | Last Updated: August 31, 2022

Two old-school college football forces slug it out as we dive headlong into the Notre Dame v Ohio State odds. 

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Here is a look at the latest game info:  

  • Date: Sept 3
  • Time 7:30 PM EST
  • Location: Ohio Stadium, Columbus, OH
  • TV Network: ABC

Notre Dame v Ohio State odds:

  • Betting favorite: Ohio State (-17)
  • Moneyline odds: Ohio State  (-750), Notre Dame (+525)
  • Point total: 59.5

Key players to watch

The Ohio State Buckeyes (#2) come into 2022 with sky-high expectations after narrowly missing out on a playoff berth last season.  The Notre Dame Fighting Irish (#5) will be looking to pick up where they left off a season ago after finishing with an 11-2 overall mark. 

Here are some key players to watch on Saturday who can shift Notre Dame v Ohio State betting odds. 

Notre Dame:

  • QB Tyler Buchner (Soph.)
  • RB Chris Tyree (Jr.) 
  • TE Michael Mayer (Jr.)
  • DE Isiah Foskey (Jr.)
  • S Brandon Joseph (Sr.) 

Ohio State:

  • QB  CJ Stroud (Soph.)
  • RB TreVeyon Henderson (Soph.)
  • WR Jaxon Smith-Njigba (Jr.)
  • DE Zach Harrison (Sr.)
  • CB Denzel Burke (Soph.)

Notre Dame v Ohio State spreads

Both programs finished 11-2 a season ago and narrowly missed out on the College Football Playoffs, but that doesn’t mean they match up evenly when sizing up the betting odds for Notre Dame v Ohio State.

Unlike NFL betting, huge spreads are common in the college game. Ohio State  (-17) is a hefty favorite to protect their home field and get their season off to the races. 

Quarterback and preseason Heisman favorite, CJ Stroud, is a significant factor in this crooked betting line as he figures to be in for a massive season.

Here is a look at some of his numbers from 2021:

  • Passing yards: 4,435
  • Touchdowns: 44
  • Interceptions: 6
  • QBR: 91.6  

Look for the Buckeyes to move the ball with ease on Saturday. Stroud led Ohio State to the #1 ranked scoring offense in the nation last season, averaging a blistering 45.7 points per game.  Expect dynamic wideout Jaxon Smith-Njigba to be heavily targeted against a Fighting Irish pass defense that conceded roughly 225 yards per game last year (ranked 62nd).

2021 ATS betting trends:

Notre Dame

  • ATS record overall: 9-4
  • ATS vs. Top-25: 1-2

Ohio State

  • ATS record overall: 6-6-1 
  • ATS vs. Top-25:  1-4

Best Notre Dame v Ohio State moneyline bets

The disparity in the Notre Dame v Ohio State lines is also reflected in the moneyline odds. 

Ohio State (-750) doesn’t have much value as a straight-up bet. However, if you lean toward Buchner and the Irish keeping things close, sprinkling a small wager on Notre Dame (+525) looks to be the far more compelling option. 

It’s worth noting that although the Buckeyes struggled against the spread vs. ranked opponents (1-4), they won three of those five contests outright.

2021 moneyline betting trends

Notre Dame

  • Moneyline record: 11-2
  • Moneyline vs. Top-25: 1-2

Ohio State

  • Moneyline record: 11-2
  • Moneyline vs Top-25: 3-2


Both of these teams were busy on the offensive end a season ago. While Ohio State led the nation in scoring, Notre Dame wasn’t far off, ranking #18, averaging over 35 points per game.

A combination of good quarterbacks and explosive playmakers has the over (59.5) looking like perhaps the most enticing of all Notre Dame v Ohio State odds.  

It is worth noting that both defensive units performed well in 2021, with Notre Dame allowing just 19.4 per game (14th) and Ohio State limiting opponents to 22.8 per contest (31st).

2021 over/under betting trends

Notre Dame

  • Over (season): 7-6
  • Over vs. Top-25: 2-1

Ohio State

  •  Over (season): 8-5
  •  Over vs. Top-25: 2-3

National Title odds

Here is a look at how each of these illustrious programs stacks up with other top contenders in the preseason national title odds: 

  • Alabama +190
  • Ohio State +320
  • Georgia +350
  • Clemson +1200
  • Notre Dame +4400

Notre Dame v Ohio State prediction

A lot of eyes will be on CJ Stroud and this super-charged Buckeyes offense. Look for Ohio State to answer the bell in Week 1 at home, even if the current Notre Dame v Ohio State odds are just a little too lopsided. 

This won’t be the biggest point total Ohio State will drop this season, but it will provide a taste of what’s to come. 

Prediction: Ohio State 38, Notre Dame 27

Notre dame at ohio state preview - odds, spreads, & moneylines