Two AFC West heavyweights slug it out as we examine the latest Chargers vs Chiefs odds and best bets. 

NFL fans will be treated to a good one this Thursday night as top contenders collide at Arrowhead Stadium in one of the league's most intriguing rivalries. 

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Chargers vs Chiefs odds

Per BetMGM

  • Betting Favorite: Chiefs  (-4)
  • Moneyline odds: Chargers (+170) , Chiefs (-200)
  • Point Total: 54.5 (over/under)
  • Location: Arrowhead Stadium, Kansas City, MO
  • TV Network: Amazon Prime

There is a lot to break down in these Chargers vs Chiefs betting odds.

The Kansas City Chiefs (-4) enter this contest as narrow home favorites. The two teams have gone blow for blow in recent meetings splitting the season series each of the past two seasons.

Oddsmakers expect a shootout with the point total set at a lofty 54.5. There will be no shortage of playmakers on both sides Thursday night. 

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Last week's performance

Both teams got off to a hot start with victories in Week 1. The Chargers edged out a 24-19 victory over the Las Vegas Raiders, while the Chiefs steamrolled the Arizona Cardinals 44-21. 

These two offenses were among the best in the league in 2021 and figure to put up some monster numbers again this season. 

NFL betting strategy is heavily influenced by who's under center. We should see some excellent quarterback play here as Patrick Mahomes and Justin Herbert are among the elite young stars in the game. The two QBs combined for eight TD passes in Sunday's openers. 

Chargers and Chiefs Injury List 

Even though it's only Week 2, both teams enter Thursday night with some significant injuries. Here's a look at some names that could impact Chargers vs Chiefs betting odds:

Chargers injuries:

  • WR Keenan Allen (questionable)
  • TE Donald Parham Jr (questionable)
  • CB J.C Jackson (questionable)

Chiefs injuries:

  • WR JuJu Smith-Schuster (questionable)
  • WR Justin Watson (questionable)
  • OT Orlando Brown Jr (questionable)
  • CB Trent McDuffie (questionable)
  • K Harrison Butker (questionable

Key receivers on both sides (Allen and Smith-Schuster) are currently listed as questionable. It will be worth monitoring their progress throughout the week as each wideout is pivotal to their team's success.

Chargers vs Chiefs head-to-head

These teams have had some memorable games in recent years. Here is a look at some betting insights from previous matchups that might shed some light on Chargers vs Chiefs odds heading into Thursday:

Chiefs trends:

  • 7-3 straight up in their last ten meetings
  • 5-4-1 ATS in their last ten meetings

Chargers trends:

  • 3-1-1 ATS in their last five meetings
  • 3-0-1 ATS in their last four games at KC

Over/under trends

  • The over is 5-5 in their last ten meetings

As we can see, while Kansas City has had the upperhand in the final score, things have tightened up more in recent years. Justin Herbert and the Chargers have either covered or pushed in their last four trips to Arrowhead. 

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Chargers recent record on the road

Thursday night will mark the Chargers' first road game of 2022.

Here is a look at how they fared on the road last season:

Chargers 2021 road trends:

  • Straight up: 4-4
  • ATS: 4-4
  • ATS as an underdog: 3-1

Chiefs recent record at Arrowhead

The Chiefs kick off their home opener on Thursday Night Football.

Here's a look at how they stacked up at Arrowhead a season ago:

Chiefs 2021 home trends (including postseason):

  • Straight up: 9-3
  • ATS: 6-6
  • ATS as the favorite: 6-6

Chargers vs Chiefs prediction

Both of these teams figure to be in the playoff hunt all season. With that said, the winner of Thursday's contest will get a massive early boost in the AFC West race. 

Both of these teams ranked in the top five in scoring in 2021, with Kansas City averaging 29.4 per game and Los Angeles 27.9. They also each ranked in the top three in passing yardage. Expect Mahomes and Herbert to air it out early and often. 

While the Chargers ranked 10th in pass defense last year, the Chiefs struggled, conceding over 250 air yards per contest (27th). We will see if Herbert can capitalize on a potentially vulnerable secondary Thursday night.

The Chargers have had no problems going into Arrowhead in recent seasons and keeping games close. Expect another nailbiter here. 

Prediction: Chargers (+4)

Chargers vs Chiefs best value bets

In a game that feels close to a coin flip, finding value in Chargers vs Chiefs odds is tricky.

Ultimately, the Chargers (+170) on the moneyline is an intriguing option, given the Chargers certainly can pull off an upset win at Arrowhead. 

Other Chargers vs Chiefs picks to consider:

  • Justin Herbert over 282.5 passing yards (-115)
  • Patrick Mahomes over 2.5 touchdowns (+105)
  • Chargers adjusted spread -3 (+210)
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