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Clemson at Wake Forest Predictions, Odds and Lines

Author: American Gambler Staff | Last Updated: September 23, 2022

Two ACC forces collide in North Carolina this weekend as we examine the latest Clemson vs Wake Forest odds and betting insights. 

Both teams come into this game with unblemished 3-0 records, but they will each be facing their toughest task of the season here. 

Clemson has National Title aspirations meaning their margin for error is razor thin. Can the Demon Deacons spring an upset and throw the Conference into chaos?

Clemson at wake forest predictions, odds and lines

Clemson vs Wake Forest odds

Per BetMGM

  • Betting Favorite: Clemson (-7.5)
  • Moneyline Odds: Clemson (-300), Wake Forest(+240)
  • Point Total: 55.5
  • Location: Truist Field, Winston-Salem, NC
  • Time/Network: 12PM on ESPN

Clemson (+1000) comes into this game with the fourth-best National Title odds in the nation behind heavy hitters Alabama, Georgia, and Ohio State. They will get a chance to make an early season statement on the road against a tough conference opponent.

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Past Weeks Performances

Both teams enter Saturday’s contest with undefeated 3-0 records. 

Clemson has rolled through Louisiana Tech, Furman, and Georgia Tech while averaging better than 41 points per game. Their average margin of victory is a hefty 27.3. 

After consecutive blowouts to begin the season, Wake Forest was challenged last week, edging out a narrow 37-36 win over Liberty. The Demon Deacons allowed an alarming 172 rushing yards so they will need to tighten things up considerably against the Tigers. 

Clemson vs Wake Forest Key Players

There will be no shortage of talent taking the field on Saturday afternoon. Here are some game-breakers to keep an eye on who have the potential to shift Clemson vs Wake Forest betting odds on a dime. 


  • QB DJ Uiagalelei (Jr.)
  • RB Will Shipley (Soph.)
  • DT Bryan Bresee (Jr.)
  • DT Tyler Davis (Sr.)

Wake Forest:

  • QB Sam Hartman (Jr.)
  • WR AT Perry  (Jr.)
  • DE Rondell Bothroyd (Jr.)
  • LB Ryan Smenda (Sr.)

Clemson vs Wake Forest head-to-head

These two storied programs have clashed on numerous occasions over the years and are very familiar with one another playing in the ACC. 

Here is a look at some betting trends from their recent history

  • Clemson is 10-0 straight up since 2012
  • Wake Forest is 5-3 ATS since 2014
  • Wake Forest is 3-2 ATS as the home team since 2012
Clemson at wake forest predictions, odds and lines

Clemson has dominated the series, winning every matchup over the last decade. However, this year's Clemson vs Wake Forest odds are much narrower than in years past. The Tigers have been a double-digit favorite in all but one game over their last ten meetings (2021). 

Clemson recent road record

Despite entering this game at 3-0, Clemson is just 1-2 against the spread. This will be their first true road game. Here’s a glance at how the Tigers fared on the road last season:

Clemson 2021 road trends

  • Straight up: 3-2
  • ATS: 2-3
  • ATS as a favorite: 2-2

Wake Forest recent record at Truist Field

Wake Forest has opened their 2022 campaign at Truist Field with a 2-0 record. They are 1-1 ATS as the home team. Here’s a look at how they performed in front of their crowd last season:

Wake Forest 2021 home trends

  • Straight up: 6-0
  • ATS: 3-3
  • ATS as an underdog: N/A

Clemson vs Wake Forest Prediction

NCAAF betting can be tricky given the larger point spreads, but that isn't a concern here.

At just seven points, the Clemson vs Wake Forest odds are much narrower than years past and an indication of how this rivalry is heating up. 

Clemson has dominated the head-to-head series this past decade, although they have not always managed to cover some rather lofty spreads. Can they cover a touchdown here? 

The Tigers will look to exploit a vulnerable Demon Deacon rushing defense that yielded 172 yards on the ground last week at Liberty. Clemson is averaging right around 200 yards per game on the ground through three contests this year. 

While Clemson is undeniably the more talented team, don’t sleep on the home crowd playing a factor here. Wake Forest hasn’t lost a game at Truist Field since 2019. Including the start of this season, Wake is a combined 12-0 the last three seasons. 

Expect a hard-fought, scrappy contest with a game that will be hanging in the balance deep into the fourth quarter. 

Prediction: Clemson 27, Wake Forest 21

Clemson vs Wake Forest best value bets

When it comes to making your Clemson vs Wake Forest picks, most of the betting value is on the Wake Forest side as a home underdog. The Wake Forest moneyline (+240) looks enticing for bettors leaning toward an upset.

As we expect a close contest here, Clemson winning by 1-6 points (+400) is the most intriguing value bet and one to keep on your radar. 


American Gambler Staff