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Steelers at Browns Predictions, Betting Odds and Lines

Author: American Gambler Staff | Last Updated: September 20, 2022

Familiar foes meet in an AFC North clash as we examine the latest Steelers vs Browns odds. 

After winning their respective openers, both teams took tough losses in Week 2. The Steelers struggled on offense, falling to the Patriots 17-14, while the Browns imploded in the final two minutes against the Jets before taking an improbable 31-30 defeat. 

Steelers at browns predictions, betting odds and lines

Steelers vs Browns odds

Per BetMGM

  • Betting Favorite: Browns (-5)
  • Moneyline Odds: Steelers +180, Browns -225
  • Point Total: 38.5 (O/U)
  • Location: FirstEnergy Stadium, Cleveland, OH
  • Time/Network: 8:15 PM EST on Amazon Prime

The Browns (-5) are sturdy favorites against their division nemesis. Steelers betting odds appear to be negatively impacted by two lackluster showings from quarterback Mitch Trubisky. Could a QB controversy be brewing in the Steel City?  

Oddsmakers are not anticipating much scoring here, with the over/under set at just 38.5

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Week 2 Performances

It was an ugly Week 2 for both franchises.

The Steelers struggled on the offensive end for 60 minutes, mustering just 14 points while losing at home.

The Browns endured one of the worst losses in NFL history, dropping a game in the final minutes when they had a 99.9% chance of winning.

Steelers vs Browns injury report

The injury report features several big names on both sides.


  • TJ Watt (IR)
  • Devin Bush (questionable)


  • Jack Conklin (out)
  • Jadeveon Clowney (out)
  • Chris Hubbard (out)
  • Jesse James (out)
  • Chase Winovich (out)

When it comes to making any Steelers vs Browns picks, the absence of TJ Watt looms large over this game.

Key players to watch 

Here's a look at some key playmakers on both sides of the ball that could shift Steelers vs Browns odds 


  • RB Najee Harris
  • WR Diontae Johnson 
  • DT Cameron Heyward
  • S Minkah Fitzpatrick


  • RB Nick Chubb
  • WR Amari Cooper
  • OG Joel Bitonio
  • DE Myles Garrett

Steelers vs Browns head-to-head

These two franchises are no strangers to one another. They meet twice a year playing in the AFC North, so there is plenty to sift through.

The Steelers have had a significant upperhand in recent years. Here are some stats to keep in mind for Steelers vs Browns betting odds on Thursday:

  • Pittsburgh is 7-3 straight up in their last ten meetings
  • Pittsburgh is 5-1 ATS in their last six meetings
  • The under is 5-2 in their last seven meetings

Steelers recent record on the road

The Steelers began the year on the road with a 23-20 upset win over Cincinnati. They enter this game 1-0 straight up and 1-0 against the spread as a road team in 2022. Here's a look at how they fared in 2021 on the road:

2021 Steelers road trends 

  • Straight up: 3-6
  • ATS: 4-5
  • ATS as an underdog: 4-5

Browns recent record at FirstEnergy Stadium

The Browns suffered a devastating home defeat yielding two touchdowns to New York within the final minutes. Cleveland is 0-1 straight up, and ATS at home in 2022. They will look to bounce back on Thursday in their second home game of the year. 

2021 Browns home trends

  • Straight up: 6-3
  • ATS: 3-6
  • ATS as a favorite: 2-6

Steelers vs Browns Prediction

Steelers vs Browns odds are among the toughest to handicap in the entire Week 3 slate.

Sporadic offenses and spotty quarterback play make it difficult to trust either one of these teams. 

Even though several betting trends favor Pittsburgh, the edge has to go to the Browns because they run the ball so well. Last year Cleveland ranked 4th in the NFL, averaging over 145 yards per game. They are averaging a blistering 200 yards per contest through two games in 2022. 

The 2021 Steelers ranked dead last in defending the run, conceding a whopping 144 per game. They haven't fared much better so far this year, allowing 128 per contest, and are without their best player in TJ Watt. 

Look for a steady dose of Nick Chubb and Kareem Hunt to grind the Steelers' defense down and take the ball out of the hands of Jacoby Brissett. 

Mitch Trubisky hasn't shown anything from the first two weeks to indicate he is an adequate NFL starter, and a change may be coming behind center soon. 

Prediction: Browns -5

Steelers at browns predictions, betting odds and lines

Best value bets

Here are some more Pittsburgh Steelers vs Cleveland Browns odds to consider

  • Nick Chubb over 77.5 rushing yards (-115)
  • Mitchell Trubisky under 202.5 passing yards (-115)
  • Browns to win and over 30.5 points scored (-105)

Steelers vs Browns FAQ