New York Giants vs San Francisco 49ers – Picks & Predictions

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New York Giants vs San Francisco 49ers – Picks & Predictions

Author: Erik Gibbs | Publish Date: September 19, 2023 | Last Updated: September 25, 2023

The Giants and 49ers are set to face off on Thursday, September 21, at Levi's Stadium in Santa Clara, California, marking the inaugural matchup of NFL Week 3. Odds for Giants vs 49ers are now available at all the best sports betting apps, with a range of compelling spreads, totals, props, and more.

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The San Francisco 49ers (2-0) have shown immense strength out of the gate. The same could be said for the New York Giants in the second half of their Week 2 clash against Arizona. The challenge in predicting this Week 3 Thursday Night Football game lies in the Giants being outscored 60-0 in the initial six quarters of the season before their furious rally on Sunday afternoon.

Head-to-Head: New York Giants Vs San Francisco 49ers

The San Francisco 49ers are aiming for their 13th consecutive regular-season triumph as they kick off Week 3 of the 2023 NFL season with their home debut.

San Francisco, currently with a 2-0 mark, wrapped up the 2022 regular season with an impressive 10-game winning streak and started the new year with road victories against the Steelers and Los Angeles Rams. The 49ers also produced 30 points in both matchups.

Meanwhile, New York, now with a 1-1 record, avoided a winless start to the season by engineering the franchise's most significant comeback of the Super Bowl era. The team managed to secure a 31-28 victory in Arizona.

New york giants vs san francisco 49ers - picks & predictions
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However, the Giants have been dealt a blow with the loss of running back Saquon Barkley, who is expected to be sidelined for approximately three weeks due to an ankle sprain.

How to Bet on the New York Giants vs San Francisco 49ers

When it comes to NFL betting, it's not merely a matter of following your instincts. The process entails a thorough examination of various factors. Top games like the Giants vs 49ers will offer bettors the perfect opportunity to make the most of every wager.

Comprehending and assessing odds is a pivotal factor in shaping bettors' decisions. Spreads, money lines, and totals represent the primary NFL betting markets. These are vital to know, understand, and interpret.

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Looking at stats, player numbers, and other trends is also important to understand how both teams might approach the game.

Finally, make sure to look for sportsbook promos offered by all top books to maximize the betting experience and provide some added security with bonus bets.

New customers can claim a $1000 first bet offer by using Caesars promo code JULIUS1000.

New York Giants vs San Francisco 49ers Odds

There’s no question that San Francisco boasts a remarkable track record as a favorite, with 13 consecutive victories in such scenarios. Additionally, they have demonstrated dominance against the spread at home, not at 13-2 ATS, and in conference matchups, now 17-4 ATS.

This puts the 49ers ahead at a hefty -530 moneyline and the over at 45 points. This also leaves San Francisco( -10.5) as prohibitive favorites according to the spread.

While underdog is almost an understatement, those who wish to favor New York can do so at a +410 moneyline. There is no question that the odds are tilted toward San Francisco as bettors prepare for a top TNF matchup between two marquee franchises.

Betting Tips for New York Giants vs San Francisco 49ers

Last Sunday, San Francisco found itself behind Los Angeles in the latter stages of the second quarter. However, they turned the tide. 

The Niners outscored the Rams 20-6 to close out a solid road win. Christian McCaffrey delivered another impressive performance on the ground, amassing 116 yards and a touchdown on 20 carries.

This type of offensive response puts bettors in a solid position to favor the 49ers. Not only do they have the offensive drive to cover the spread, but may just have what it takes to hit the over 45 points line.

Here are some trends to consider:

  • In their last 13 games, the 49ers are 13-0 SU as the favorite
  • Giants are also 2-9 SU in their last 11 TNF appearances
  • Against NFC West division rivals, the Giants are 3-10 SU

New York Giants vs. San Francisco 49ers Predictions

The Giants find themselves significant underdogs. While the NFL often sees substantial upsets, it appears unlikely that the Giants will have a chance of making it past the 49ers on Thursday night without star running back Saquon Barkley.

While the 49ers showed some cracks last week, they boast a roster as formidable as any in the NFL. Look for them to thrive in front of a raucous home crowd and dominate an undermanned New York squad.

Prediction: 49ers -10.5 

Erik Gibbs

Erik is a dynamic and seasoned journalist with a passion for all things sports and sports betting. With a career spanning over two decades, he has become a prominent figure in the world of sports journalism, admired for his insightful analysis and engaging storytelling.