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Florida State vs Clemson – Picks & Predictions
The Atlantic Coastal rivals will meet early this year – Florida State and Clemson are kicking off this Saturday in one of the most anticipated matchups of the Week 4 slate.
Disclaimer
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- Game Time: 12:00 PM ET
- Location: Memorial Stadium, Clemson, South Carolina
Head-to-Head: Florida State vs Clemson
Florida State and Clemson have faced off several times in recent memory, but the Tigers have left victorious after each of the last seven times. They’ve covered the spread in each of the last five. The last time the Seminoles beat the Tigers was in 2014 – when Sean McGuire filled in for Jameis Winston at quarterback to help Florida State to a 23-17 win.
Unless the lines drastically change, this will be the first meeting between these teams since that 2014 game where the Seminoles enter as the favorite to win. Florida State is 3-0 this season after closing the 2022 season with six consecutive wins, and they currently occupy a high position in both the AP Top 25 (3) and Coaches Poll (4).

Clemson’s public perception is far more tenuous, with a 7-28 loss to Duke in Week 1 still hanging on their stock like an anchor. After closing 2022 with a 3-3 record in six games they were favored to win, the Tigers aren’t nearly as highly regarded as they were during their playoff runs only a couple of seasons ago. A win on Saturday could quickly restore their image, but a loss will probably drop the Tigers from the playoff conversation for another year.
How to Bet on the Florida State vs Clemson
Online sportsbooks across America will offer markets on the Clemson at Florida State game, and will likely make the game among their more publicized events heading into the weekend. Few sports are more popular with American bettors than college football, and few games this weekend will draw more attention on college football betting sites. Be sure to check your available sportsbooks to find the best lines, as well as any unique props you’d be inclined to bet on. Use Caesars promo code JULIUS1000 and claim a $1000 first bet on Caesars.
Disclaimer
In addition, make sure to keep up with any injury updates or any other news that would impact player availability as kickoff approaches. Major injury news will have a visible impact on the lines, but lower-profile players being unable to play can still easily impact the outcome of the game. Don’t let a critical injury catch you by surprise after your bet slip is submitted.
Florida State vs Clemson Odds
- Money Line: CLEM +112, FSU -134
- Spread: FSU -2.5
- Total: o/u 55.5
Betting Tips for Florida State vs Clemson
- FSU is 9-0 in their last nine games.
- CLEM is 14-1 in their last fifteen home games.
- The over is 6-0 in FSU’s last six games.
- The over is 4-1-1 in the last six CLEM-FSU meetings.
Florida State vs Clemson Predictions
While a Clemson win wouldn’t be overly shocking, Florida State has made a compelling case so far that this is their season to run the ACC. Despite that, Clemson boasts an incredibly impressive home record – prior to a 30-31 loss to South Carolina last season, the Tigers’ last home loss was a 42-43 loss to Pittsburgh in 2016. Traveling to Clemson and leaving with a win would be an incredibly emphatic statement by the Seminoles that they’re a championship contender this season.
Many fans will look at the Tigers’ home record, the potential payout of taking them given the status of the odds, and make their bet. History can be instructive, but it’s important for bettors to not be a prisoner of it. FSU is favored to win, despite their opponent and location, for a reason.
Prediction: Florida State -2.5