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NCAA March Madness South Region First Round Odds, Predictions For Every Game

Author: americangambler | Last Updated: March 16, 2021

When the NCAA Men’s Tournament March Madness bracket was finalized Sunday night, bettors were already on the prowl looking for the best First Round games to wager.

The South Region should have some interesting battles Friday, as it tips off the 16-game festivities. 

Here is a look at all eight games in the South, with predictions, odds, and underdog plays for you.

4-Purdue (-350) vs. 13-North Texas (+280), 7:25 p.m. EDT (TNT). Purdue -7.5, total 126.5

This Purdue team can make a legitimate run to the Final Four with a couple breaks. This line today looks very tempting. The Pick: Purdue -7.5.

Check other picks below (Check for channel listings):

Predictions for NCAA South Region First Round Games:

BEST BET: Purdue -7.5