5-Villanova (-300) vs. 12-Winthrop (+240), 9:57 p.m. EDT (TNT). Odds and prediction for Villanova: -6.5, total 142.5.
The Pick: Winthrop +6.5, Winthrop ML (+240)
Villanova comes into the bracket with a major season-ending injury to Colin Gillispie, and has Justin Moore hobbled as well with an ankle injury. And the Cats have not been playing well. Then, they look up and see a one-loss Winthrop team that is probably mad because it was underseeded in the bracket. Oh yeah, this is a 5-12 game. Might as well print Upset all over it.