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Giants at Cowboys Odds, Lines and Predictions

Author: AmericanGambler1234 | Last Updated: September 23, 2022

Another heated division rivalry returns as we take a closer look at Cowboys vs Giants odds.

Both teams have proven difficult to pin down so far through 2022, with the Cowboys earning a win at home last week with backup quarterback Cooper Rush at the helm and the Giants coming out to the most surprising 2-0 start of the season under new head coach Brian Daboll.

They’ll meet this week on Monday Night Football in a game that the oddsmakers project to be as narrowly decided as any this week.

Giants at cowboys odds, lines and predictions

Cowboys vs Giants Odds

Per BetMGM

  • Betting Favorite: Giants -1.0
  • Moneyline Odds: Cowboys -101, Giants -115
  • Point Total: 39 Over/Under
  • Location: MetLife Stadium, East Rutherford, NJ
  • Time/Network: 8:15 PM EST | ESPN

The Giants are one of three teams to be favored by a single point this week, but a victory for them would be a departure from recent history between the two teams. The Cowboys and Giants have played ten times since 2017; the Giants left with a win in only one of those games.

The teams have split hitting the point total in those games but have hit the over in five of their last seven meetings. Only one of those meetings had a point total set lower than 39, and the teams have scored over 39 points – usually significantly more – in six of those seven games.

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Cowboys vs Giants Injury Report

The Cowboys and Giants enter the week with a combined 18 players on their injury report, with 11 of them coming from the Giants. It will be worth monitoring this list as kick-off approaches as several it could impact Cowboys vs Giants betting odds.

Cowboys Injury Report

  • CB Trevon Diggs (Non-Injury/Personal)
  • WR Michael Gallup (Knee)
  • S Jayron Kearse (Knee)
  • G Connor McGovern (Ankle)
  • LB Micah Parsons (Illness)
  • QB Dak Prescott (Right Thumb)
  • TE Dalton Schultz (Knee)

Giants Injury Report

  • DB Justin Layne (Concussion)
  • DB Nick McCloud (Hamstring)
  • WR Wan’Dale Robinson (Knee)
  • DL Leonard Williams (Knee)
  • DB Dane Belton (Clavicle)
  • C Jon Feliciano (Shin)
  • OLB Azeez Ojulari (Calf)
  • DB Aaron Robinson (Appendix)
  • DB Jason Pinnock (Shoulder)
  • OLB Kayvon Thibodeaux (Knee)
  • WR Kadarius Toney (Hamstring)

The Cowboys have several big names on their report. Dak Prescott remains several weeks away from returning to the field, while Diggs and Parsons should be clear to play.

The Giants’ litany of injured defensive backs warrants concern, but their greatest optimism on this report comes in the form of Azeez Ojulari and Kayvon Thibodeaux. Both starting edge defenders were limited participants in practice after missing the first two games of the season – they’ll be a huge boon to the Giants’ defense if they’re ready to go against the Cowboys.

Key Players to Watch

Here’s a handful of players that could significantly impact the Cowboys vs Giants odds:


  • QB Cooper Rush
  • WR Noah Brown
  • LB Micah Parsons
  • SS Israel Mukuamu


  • RB Saquon Barkley
  • WR Richie James
  • WR Sterling Shepard
  • S Julian Love

It goes without saying that the quarterback is a key player for a football team, but there’s a lot of variance in the performance of backups. Cooper Rush played well enough last week against the Bengals to give the Cowboys a chance to win. He’ll need to do that again if the team has any hope of coming out Monday at 2-1.

Noah Brown has been the primary beneficiary of the Cowboys’ injury depletion at the receiver position, leading the team in receptions, yards, and touchdowns. He’ll need to continue stepping up against the Giants in order for the team to win.

Parsons’ presence or absence on defense will swing the game immensely – the second-year linebacker was peerless through the team’s first two games, racking up four tackles for loss, seven quarterback hits, and four sacks. Mukuamu saw an uptick in snaps against the Bengals with Jayron Kearse sidelined and looked impressive – he’ll need to continue doing so with how much Dallas relies on their safeties to play a wide array of roles in their defense.

The Giants' offense has run through Saquon Barkley for two consecutive weeks to open the season, with the back carrying the ball a total of 39 times for 236 yards. He also ranks second on the team in receptions and third in receiving yards.

Sterling Shepard and Richie James have been playing well above their pay grades and will need to continue doing so if Wan’Dale Robinson misses more time and Kenny Golladay remains mysteriously absent from the offense.

Julian Love leads the team in tackles and ties for the team lead in tackles for loss and sacks. If the Giants’ secondary health doesn’t improve, he may be leaned on even harder as the season continues.

Cowboys vs Giants Head to Head

Here are some betting insights from their recent matchups that might shed light on Cowboys vs Giants odds ahead of Monday night.


  • 9-1 straight up in their last ten meetings.
  • 8-2 ATS in their last ten meetings.


  • 2-2 ATS in their last four meetings.
  • They were home for their last victory against the Cowboys, straight up and against the spread.

Cowboys Recent Record on the road

  • 4-0 straight up and against the spread in their last four road games to end the 2021 season.
  • Haven’t yet played a road game in the 2022 season.

Giants Recent Record at Metlife

  • 0-3 straight-up to end the 2021 season, but won their home opener in 2022.
  • 2-2 against the spread in their last 4 home games.

Cowboys vs Giants Prediction

The Giants have played better than the sum of their parts to open the season and are likely to lose their first game sooner than later, but the Cowboys have done little to inspire faith that they’ll be the team to knock their division rival off.

The injury report bears watching up until kickoff, but Daboll has coached the most out of the roster the Giants have given him. Unless something changes there, he won’t allow the Cowboys to beat him as easily as they were able to beat the Bengals last week. It’s a tiny margin, but he's earned the 1-point favor the oddsmakers have given the Giants.

Prediction: Giants -1

Giants at cowboys odds, lines and predictions

Cowboys vs Giants Best Value Bets

Here are some additional Cowboys vs Giants picks to consider:

  • Over 39.5 (-105)
  • Winning Margin: Giants by 1-6 (+320)
  • Graham Gano Over 6.5 Kicking Points (-125)

Cowboys at Giants FAQ