U 52 is an abbreviation for under 52, which represents the total number of points scored in an NFL game, a standard line found on the best betting apps.
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Over/under bets are very common among bettors who wager on NFL betting sites. The oddsmakers come up with a number for the total score of the game they feel is fair to both sides, and as they do with the point spread, a number that will generate equal money on both sides.
Say the Denver Broncos are playing the Indianapolis Colts. After displaying the point spread and the moneyline odds, the 3rd row represents the point total. It could look something like this:
In this instance, that number was 52 points. And the U 52 means a bet on less than a combined 52 points scored between the two teams.