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49ers vs Panthers Preview

  • Betting Favorite: 49ers -6.5
  • Moneyline Odds: 49ers -275, Panthers +220
  • Location: Bank of America Stadium, Charlotte, NC
  • Time/Network: 4:05 PM ET | CBS

On one side of the field, the 49ers (2-2) have outscored their last three opponents 62-26 – including a decisive 24-9 win over the rival Rams last Monday. On the other side, the Panthers (1-3) managed to take a win from the Saints in Week 3 but have otherwise been disappointing.

Offensively, the Panthers rank dead last in total yards per game – 30th in passing yards and 24th in rushing yards. Baker Mayfield has struggled in his first season with the team, looking like hardly more than an expensive lateral move from 2021 starter Sam Darnold.

Christian McCaffrey and D.J. Moore haven't made the kind of plays they'd need to buoy the offense as it's currently structured. The most positive story around the team might be the box score dominance of linebacker Frankie Luvu.

The 49ers, after losing starting quarterback Trey Lance to injury in Week 2, have battled back to an even record and are reasserting their offensive identity with Jimmy Garoppolo under center.

San Francisco is shaping up to be a contender, despite their 0-2 start on the road this season. It's a trend they'll look to buck against a vulnerable Panthers team, but don't be surprised if the Panthers rally should the 49ers once again forget to pack their offense.

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