San Francisco 49ers vs Seattle Seahawks – Picks and Predictions

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San Francisco 49ers vs Seattle Seahawks – Picks and Predictions

Author: Andy Hammel | Publish Date: November 21, 2023 | Last Updated: November 21, 2023

Thanksgiving night of the 2023 NFL season will close out with a division matchup between two NFC contenders in the Seattle Seahawks (6-4) and the visiting San Francisco 49ers (7-3). Betting markets will be available at all online sportsbooks, including money lines, spreads, totals, and various props to choose from. There will also be a slew of betting promos for the big game.

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Head-to-Head: San Francisco 49ers vs Seattle Seahawks

San Francisco and Seattle have played several times over the past several years – they play twice a year in the regular season as division rivals, but last met in the wildcard round of the playoffs last season. They’ve split the last ten games evenly, but the 49ers have walked out of the last three meetings victorious.

The 49ers are two weeks removed from a three-game losing skid, and most recently won 27-14 against the Tampa Bay Buccaneers. That’s the only win of their season thus far in which the 49ers scored fewer than 30 points. Their 387.0 yards per game on the season ranks 3rd in the NFL, and their 27.9 points per game ranks 4th. Defensively, the 49ers allow a league-low 15.7 points per game.

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The Seahawks are coming off a 16-17 loss to the Los Angeles Rams, their second loss to the Rams this season and their third consecutive loss on the road. That first loss to the Rams notwithstanding, however, the Seahawks have won each of their home games this season. The team ranks toward the middle of the pack in yards (327.4) and points (21.6) per game, ranking 18th and 16th respectively. Both sides of the ball figures to have their hands full against the 49ers.

How to Bet on San Francisco 49ers vs Seattle Seahawks

Sports betting apps around America will feature markets on the 49ers vs Seahawks game. Make sure to check your available options to find the best odds, as well as any unique prop bets or promotions that one NFL betting site may have over another.

Additionally, make sure to check each team’s injury report before placing any bets. While the report can still leave room for ambiguity, it’s prudent to know where each team and roster stands before making any relevant wagers. Don’t wait until after you’ve made a bold wager to find out that a key player in the game won’t actually be playing in it.

San Francisco 49ers vs Seattle Seahawks Odds

  • Money Line: SF -295, SEA +240
  • Spread: SF -7.0
  • Total: o/u 42.5

Betting Tips for San Francisco 49ers vs Seattle Seahawks

  • SF is 1-4 ATS in their last five games.
  • SF is 1-3 ATS in their last four road games.
  • SEA is 4-0 in their last four home games.
  • SEA is 1-4-1 ATS in their last six games.
  • The Under is 3-1-1 in the 49ers last five road games.

San Francisco 49ers vs Seattle Seahawks Predictions

We’ve seen enough variance in both teams’ play over the past few weeks to make this one hard to predict. If the 49ers show up on Thursday night and look like the best version of themselves we’ve seen in 2023, they’ll win. Doesn’t matter what the Seahawks do, or whether they suddenly transform into any of the other 30 teams – that statement isn’t about them. That’s on the table, but it’s not safe to assume that’s the version of the 49ers we’ll see.

The Seahawks won’t want to follow their second loss to the Rams with a home loss to the 49ers, which would put them at 1-3 in the division with trips to Glendale and Santa Clara to go. This is a big game for them, and winning it would put them at 7-4 and the lead position in the NFC West by tiebreaker.

Prediction: Seattle Seahawks +7

Andy Hammel

Andy is our resident NFL expert, but his knowledge extends to all corners of the sports betting industry. Andy is always tracking betting trends and keeping you up to date on all the relevant news in your home state.