Notre Dame vs Duke – Picks and Predictions

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Notre Dame vs Duke – Picks and Predictions

Author: Andy Hammel | Publish Date: September 29, 2023 | Last Updated: September 29, 2023

Durham will be host to one of the most anticipated games of the college football weekend as the Notre Dame Fighting Irish (4-1) prepare to travel to play the undefeated Duke Blue Devils (4-0).

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Markets figure to be available on all major betting apps, with a range of props available to support the money lines, spreads, and totals that all online sportsbooks will carry.

  • Game Time: 7:30 PM ET
  • Location: Wallace Wade Stadium, Durham, NC

Head-to-Head: Notre Dame vs Duke

The Irish are coming off possibly the best game of last weekend, where they fell 17-14 to annual powerhouse Ohio State on a (literal) last-second touchdown from the Buckeyes with only 10 players on the field for the Irish defense. They’ll be looking to get back in the win column this week against Duke, a team they’ve soundly beaten in each of their last two matchups dating back to 2019.

The Blue Devils are 4-0 and several weeks removed from their dominant win over Clemson that put them on the map this season, but they’ve taken care of business against inferior opponents in each of the last three weeks. They covered a 22-point spread as the favorite against UConn last week, one week after they covered a 17-point spread as favorites against Northwestern. Altogether, Duke has outscored their opponents 149-35 this season – Notre Dame figures to give them a greater challenge.

How to Bet on Notre Dame vs Duke

Sportsbooks across the country will offer markets for Notre Dame and Duke, and will likely make the game a central part of their marketing, with Durham hosting ESPN College GameDay. Be sure to check your available sportsbook promos and betting options to find the best lines and any special props you might be inclined to bet on.

Beyond that, make sure to keep up with injury updates as the game approaches, or any other news that would impact player availability or lines.

Notre Dame vs Duke Odds

  • Money Line: ND -220, DUKE +180
  • Spread: ND -5/5
  • Total: o/u 54.5

Betting Tips for Notre Dame vs Duke

  • ND is 4-1 in their last five away games.
  • ND has hit the first half money line in 10 of their last 13 games.
  • ND has hit the over in 8 of their last 10 games.
  • DUKE is 8-2 ATS in their last ten games.
  • Duke is 4-0 ATS in their last four games as underdogs.

Notre Dame vs Duke Predictions

Whichever team wins this game, it’ll be a statement game that significantly helps the winner in the AP and Coaches Poll rankings. Both teams have scored at will against more of their opponents than not, and Duke has a great chance to cover the spread if they don’t win outright.

That said, Notre Dame is the team that needs the win more and there’s a good case they’re the better team anyway. Their defense ranks near the top of the league in several key metrics, including yards allowed (260.6 per game), passing yards allowed (149.4 per game) and completion percentage allowed (47.4, the best mark in Division I). 

Betting on the Notre Dame offense to secure the cover against a Duke defense that hasn’t been nearly as dominant feels like a safer bet.

Prediction: Notre Dame -5.5

Andy Hammel

Andy is our resident NFL expert, but his knowledge extends to all corners of the sports betting industry. Andy is always tracking betting trends and keeping you up to date on all the relevant news in your home state.