Liverpool and Manchester United, teams with two of the five best odds to lift the cup in May, play Sunday in the tie of the round.
There are 32 teams left in the 2020-2021 F.A. Cup, which means that just 16 clubs will be left standing once the 16 games are played out this weekend.
Starting Friday with Chorley FC hosting Premier League side Wolverhampton, and running through Monday evening’s contest with Wycombe hosting Tottenham, the teams will play until there is a winner to move on to the Fifth Round, which starts midweek February 9-11.
There are still 13 Premier League teams left in the competition, but that number will be whittled down by at least three after this weekend, thanks to three top flight match ups, including the tie of the round which pits Manchester United against Liverpool. The other two games pitting Premier League sides are Southampton against defending champion Arsenal Saturday and Fulham against Burnley Sunday.
F.A. Cup Fourth Round Betting
Right now, Manchester City is the clear favorite to lift the cup in May at odds of +225. Three London teams make up four of the next five odds: Chelsea (+600), Tottenham (+700), and Arsenal (+1200), with Liverpool at +800. Manchester United and Leicester City are both at +1200, but those odds should come down dramatically for the Red Devils if they get past Liverpool this weekend.
The draw for the Fifth Round has already taken place, so teams will know their opponent once they advance through the weekend. With no replays this season to reduce fixture congestion, all games will be decided in added extra time and possibly penalties.
Here is a list of all games this weekend, with times and television channels included. All games are streamed on the ESPN+ platform.
F.A. Cup Fourth Round Schedule (All games streamed on ESPN+)
Chorley FC vs. Wolverhampton Wanderers, 2:45 p.m. EST
Southampton vs. Arsenal, 7:15 a.m. EST
West Ham United vs. Doncaster Rovers, 10 a.m. EST
Sheffield United vs. Plymouth Argyle, 10 am. EST
Swansea City vs. Nottingham Forest, 10 a.m. EST
AFC Bournemouth vs. Crawley Town, 10 a.m. EST
Brighton & Hove Albion vs. Blackpool, 10 a.m. EST
Barnsley vs. Norwich City, 10 a.m. EST
Millwall vs. Bristol City, 10 a.m. EST
Cheltenham Town vs. Manchester City, 12:30 p.m EST
Chelsea vs. Luton Town, 9:30 a.m. EST
Fulham vs. Burnley, 9:30 a.m. EST
Brentford vs. Leicester City, 9:30 a.m. EST
Manchester United vs. Liverpool, 12 p.m. EST
Everton vs. Sheffield Wednesday, 3 p.m. EST
Wycombe Wanderers vs. Tottenham Hotspurs, 2:45 p.m. EST